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NKX3.1’s downregulation is strongly associated with prostate cancer (PCa) initiation, progression, and CRPC development. Nevertheless, a clear disagreement exists between NKX3.1 protein and mRNA levels in PCa tissues, indicating that its regulation at a post-translational level plays a vital role. This study identified a strong negative relationship between NKX3.1 and LIMK2, which is critical in CRPC pathogenesis. We identified that NKX3.1 degradation by direct phosphorylation by LIMK2 is crucial for promoting oncogenicity in CRPC cells and in vivo. LIMK2 also downregulates NKX3.1 mRNA levels. In return, NKX3.1 promotes LIMK2’s ubiquitylation. Thus, the negative crosstalk between LIMK2-NKX3.1 regulates AR, ARv7, and AKT signaling, promoting aggressive phenotypes. We also provide a new link between NKX3.1 and PTEN, both of which are downregulated by LIMK2. PTEN loss is strongly linked with NKX3.1 downregulation. As NKX3.1 is a prostate-specific tumor suppressor, preserving its levels by LIMK2 inhibition provides a tremendous opportunity for developing targeted therapy in CRPC. Further, as NKX3.1 downregulates AR transcription and inhibits AKT signaling, restoring its levels by inhibiting LIMK2 is expected to be especially beneficial by co-targeting two driver pathways in tandem, a highly desirable requisite for developing effective PCa therapeutics. 

We report measurements of production cross sections for ${\rho }^{+}$, ${\rho }^0$, $\omega$, $K^{*+}$, $K^{*0}$, $\varphi$, $\eta$, $K_S^0$, $f_0\left(980\right)$, $D^{+}$, $D^0$, $D_s^{+}$, $D^{*+}$, $D^{*0}$, and $D_s^{*+}$in $e^{+}{e}^{-}$collisions at a center-of-mass energy near 10.58 GeV. The data were recorded by the Belle experiment, consisting of $571{\mathrm{fb}}^{-1}$at 10.58 GeV and $74{\mathrm{fb}}^{-1}$at 10.52 GeV. Production cross sections are extracted as a function of the fractional hadron momentum $x_p$. The measurements are compared to Monte Carlo generator predictions with various fragmentation settings, including those that have increased fragmentation into vector mesons over pseudoscalar mesons. The cross sections measured for light hadrons are consistent with no additional increase of vector over pseudoscalar mesons. The charmed-meson cross sections are compared to earlier measurements—when available—including older Belle results, which they supersede. They are in agreement before application of an improved initial-state radiation correction procedure that causes slight changes in their $x_p$shapes. Published by the American Physical Society2025 

Abstract Despite the f₀(980) hadron having been discovered half a century ago, the question about its quark content has not been settled: it might be an ordinary quark-antiquark ($${{\rm{q}}}\overline{{{\rm{q}}}}$$ $q\overline{q}$) meson, a tetraquark ($${{\rm{q}}}\overline{{{\rm{q}}}}{{\rm{q}}}\overline{{{\rm{q}}}}$$ $q\overline{q}q\overline{q}$) exotic state, a kaon-antikaon ($${{\rm{K}}}\overline{{{\rm{K}}}}$$ $K\overline{K}$) molecule, or a quark-antiquark-gluon ($${{\rm{q}}}\overline{{{\rm{q}}}}{{\rm{g}}}$$ $q\overline{q}g$) hybrid. This paper reports strong evidence that the f₀(980) state is an ordinary$${{\rm{q}}}\overline{{{\rm{q}}}}$$ $q\overline{q}$meson, inferred from the scaling of elliptic anisotropies (v₂) with the number of constituent quarks (n_q), as empirically established using conventional hadrons in relativistic heavy ion collisions. The f₀(980) state is reconstructed via its dominant decay channel f₀(980) →π⁺π⁻, in proton-lead collisions recorded by the CMS experiment at the LHC, and itsv₂is measured as a function of transverse momentum (p_T). It is found that then_q= 2 ($${{\rm{q}}}\overline{{{\rm{q}}}}$$ $q\overline{q}$state) hypothesis is favored overn_q= 4 ($${{\rm{q}}}\overline{{{\rm{q}}}}{{\rm{q}}}\overline{{{\rm{q}}}}$$ $q\overline{q}q\overline{q}$or$${{\rm{K}}}\overline{{{\rm{K}}}}$$ $K\overline{K}$states) by 7.7, 6.3, or 3.1 standard deviations in thep_T< 10, 8, or 6 GeV/cranges, respectively, and overn_q= 3 ($${{\rm{q}}}\overline{{{\rm{q}}}}{{\rm{g}}}$$ $q\overline{q}g$hybrid state) by 3.5 standard deviations in thep_T< 8 GeV/crange. This result represents the first determination of the quark content of the f₀(980) state, made possible by using a novel approach, and paves the way for similar studies of other exotic hadron candidates. 

A first search for beyond the standard model physics in jet multiplicity patterns of multilepton events is presented, using a data sample corresponding to an integrated luminosity of $138{\mathrm{fb}}^{-1}$of 13 TeV proton-proton collisions recorded by the CMS detector at the LHC. The search uses observed jet multiplicity distributions in one-, two-, and four-lepton events to explore possible enhancements in jet production rate in three-lepton events with and without bottom quarks. The data are found to be consistent with the standard model expectation. The results are interpreted in terms of supersymmetric production of electroweak chargino-neutralino superpartners with cascade decays terminating in prompt hadronic $R$-parity violating interactions. 

A search for the rare decay $D^0\to {\mu }^{+}{\mu }^{-}$is reported using proton-proton collision events at $\sqrt{s}=13.6\mathrm{TeV}$collected by the CMS detector in 2022–2023, corresponding to an integrated luminosity of $64.5{\mathrm{fb}}^{-1}$. This is the first analysis to use a newly developed inclusive dimuon trigger, expanding the scope of the CMS flavor physics program. The search uses $D^0$mesons obtained from $D^{*+}\to D^0{\pi }^{+}$decays. No significant excess is observed. A limit on the branching fraction of $\mathcal{B}(D^0\to {\mu }^{+}{\mu }^{-})<2.4\times {10}^{-9}$at 95% confidence level is set. This is the most stringent upper limit set on any flavor changing neutral current decay in the charm sector. 

A<sc>bstract</sc> A search for a heavy pseudoscalar Higgs boson, A, decaying to a 125 GeV Higgs boson h and a Z boson is presented. The h boson is identified via its decay to a pair of tau leptons, while the Z boson is identified via its decay to a pair of electrons or muons. The search targets the production of the A boson via the gluon-gluon fusion process, gg → A, and in association with bottom quarks,$$\text{b}\overline{\text{b}}\text{A }$$. The analysis uses a data sample corresponding to an integrated luminosity of 138 fb⁻¹collected with the CMS detector at the CERN LHC in proton-proton collisions at a centre-of-mass energy of$$\sqrt{s}=13$$TeV. Constraints are set on the product of the cross sections of the A production mechanisms and the A → Zh decay branching fraction. The observed (expected) upper limit at 95% confidence level ranges from 0.049 (0.060) pb to 1.02 (0.79) pb for the gg → A process and from 0.053 (0.059) pb to 0.79 (0.61) pb for the$$\text{b}\overline{\text{b}}\text{A }$$process in the probed range of the A boson mass,m_A, from 225 GeV to 1 TeV. The results of the search are used to constrain parameters within the$${\text{M}}_{\text{h},\text{EFT}}^{125}$$benchmark scenario of the minimal supersymmetric extension of the standard model. Values of tanβbelow 2.2 are excluded in this scenario at 95% confidence level for allm_Avalues in the range from 225 to 350 GeV. 

Future tactical communications involves high data rate best effort traffic working alongside real-time traffic for time-critical applications with hard deadlines. Unavailable bandwidth and/or untimely responses may lead to undesired or even catastrophic outcomes. Ethernet-based communication systems are one of the major tactical network standards due to the higher bandwidth, better utilization, and ability to handle heterogeneous traffic. However, Ethernet suffers from inconsistent performance for jitter, latency and bandwidth under heavy loads. The emerging Time-Triggered Ethernet (TTE) solutions promise deterministic Ethernet performance, fault-tolerant topologies and real-time guarantees for critical traffic. In this paper we study the TTE protocol and build a TTTech TTE test bed to evaluate its performance. Through experimental study, the TTE protocol was observed to provide consistent high data rates for best effort messages, determinism with very low jitter for time-triggered messages, and fault-tolerance for minimal packet loss using redundant networking topologies. In addition, challenges were observed that presented a trade-off between the integration cycle and the synchronization overhead. It is concluded that TTE is a capable solution to support heterogeneous traffic in time-critical applications, such as aerospace systems (eg. airplanes, spacecraft, etc.), ground-based vehicles (eg. trains, buses, cars, etc), and cyber-physical systems (eg. smart-grids, IoT, etc.).